{"text_format":"3","workbook":"xlsx","n_sheets":6,"sheets":["Instructions","ControlCenter","Genetic Parameters","Selection Index Sheet","Economic values - Indexes","Age optimization"],"not_rendered":{"charts":1,"images":4,"macros":1,"defined_names":6,"comments":4},"read":"whole","date_system":"1900"}

{"sheet":"Instructions","index":0,"n_rows":56,"n_cols":19,"rows_kept":56}
["This GENSEL spreadsheet combines:"]
[null,1,"MTINDEX: Multi Trait Selection Index: works out optimal weights, accurcay of MTEBVs and selection response"]
[null,2,"Optimizes selection across age classes (it calculates index accuracy for each age class and each sex and optimizes generation interval)"]
[null,3,"GenomicSelection (modeled by defining a  \"VQTL\" for each trait, i.e. what proportion of VA can be predicted)"]
[null,4,"Various  industry indexes to be implemented. Can choose an index and the objective traits as well as the 'measured traits' will populate the main sheet."]
[]
[]
[]
[null,null,"Use CONTROL CENTRE as your main sheet. It borrows genetic parameters and economic values from other sheets",{"$nulls":10},"Genetic and phenotypic parameters are given as varinaces on diagonal and correlations on off diagonal, h2 in column F"]
[{"$nulls":3},"After you change 1) which index is used  or 2) which traits you measure, you need to run the purple button"]
[]
[{"$nulls":5},"        This button will set up the index, and outputsinformation to the selection index sheet"]
[{"$nulls":5},"      Cell A20 is a dropdown with index names"]
[{"$nulls":12},"Trait","Trait","Trait","Age at",null,"Trait"]
[{"$nulls":3},"Important information needs to be given about  ",{"$nulls":7},"TRAIT RECORDING             ","Abbreviation","Measurement","Measurement","Measurement","Economic","Measured","Genomic "]
[{"$nulls":13},"Males","Females","in time units","Value"," in RefPop 0/1","reliability"]
[{"$nulls":5},"a trait will only be seen if there s a trait abbreviation (column B)",{"$nulls":5},"Genotyping","DNA",1,0]
[{"$nulls":11},"Birth weight","bwt",0,0,0,null,{"v":1,"d":"1.00"},{"v":0.022000000000000002,"d":"0.0220"}]
[{"$nulls":3},"To calculate the gain for a given scenario, push the purple button in 9C-10E"]
[{"$nulls":4},"scenarios can be defined by flock structure, mating ratio, age at selection, etc."]
[{"$nulls":4},"but also by whether a trait is measured(males/females) or there is a GBV"]
[{"$nulls":10},"      This button will show result of one run"]
[{"$nulls":10},"     and compare them with the previous run"]
[]
[{"$nulls":3},"or",null,null,"if you want to compare the same scenario with and without genomic seection"]
[{"$nulls":6},"it will take the genomic selection scenario as defined in cells 24 CD "]
[{"$nulls":6},"(e.g. malesgenotyped only, males + females genotyped)"]
[]
[]
[{"$nulls":3},"The",null,"button allows you to graph the accurcaues for each age class"]
[{"$nulls":5},"for a certain trait or the index "]
[{"$nulls":5},"Cell F6 is a dropdown with trait names"]
[{"$nulls":14},"These buttons will uses a macro, so you need to allowExcel  usage of macros"]
[{"$nulls":3},"The parameter matrix sheet  is hidden"]
[{"$nulls":3},"The economic values sheet is hidden"]
[{"$nulls":3},"You can look at these sheets by 'unhide' (right click on sheet tabs)  "]
[{"$nulls":3},"You can edit the indexes and  add your own index with economic values  "]
[]
[null,null,"The program checks whether genetic parameters are consistent (positive definite correlation matrices)"]
[null,null,"It does not handle",null,"Desired Gains",null,"(see for this MTINDEX_DESGAIN)"]
[{"$nulls":4},"Multiple Stage Selection"]
[]
[]
[]
[]
[]
[]
[null,null,"Produced by",null,"Julius van der Werf"]
[{"$nulls":4},"University of New England"]
[{"$nulls":4},"Armidale, Australia"]
[{"$nulls":4},"julius.vanderwerf@une.edu.au"]
[{"$nulls":4},"http://www-personal.une.edu.au/~jvanderw/"]
[]
[]
[{"$nulls":4},"other tools:"]
[{"$nulls":4},"http://www-personal.une.edu.au/~jvanderw/software.htm"]

{"sheet":"ControlCenter","index":1,"n_rows":60,"n_cols":21,"rows_kept":60}
["Control Centre"]
["INPUT","light blue tends to be a parameter input cell"]
["FLOCK STRUCTURE",{"$nulls":11},"Accurcay EBV",null,"Age Structure"]
["Nr of breeding females",60,"if used in year 1",{"$nulls":4},13.873740771470425,{"$nulls":3},"Age","Accuracy for","t1","age at","total nr in  ",null,"               Nr Selected  (latest run)",null,"   Preset Age Structure"]
["Mating ratio (females/male)",3,3,null,null,"trait",{"$nulls":5},"class","males","females","prog drop","age class","mean","males","females","males","females"]
["Nr sires used per year",{"v":20,"d":"20.0"},{"$nulls":3},"t1",{"$nulls":5},1,{"v":0.613973412115981,"d":"0.614"},{"v":0.3872983346207416,"d":"0.387"},1,480,{"v":6.703445068255341,"d":"6.70"},{"v":19.809254532738976,"d":"19.8"},{"v":59.381114092086364,"d":"59.4"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"}]
["Weaning rate",{"v":8,"d":"800%"},{"v":8,"d":"800%"},{"$nulls":8},{"$f":"L6+1","v":2},{"v":0.730396884544797,"d":"0.730"},{"v":0.6456742246778457,"d":"0.646"},{"$f":"O6+1","v":2},{"v":465.59999999999997,"d":"466"},{"v":5.958617838449192,"d":"5.96"},{"v":0.18175652819471322,"d":"0.2"},{"v":0.6027948643767029,"d":"0.6"},{"v":4,"d":"4.0"},{"v":100,"d":"100.0"}]
["Nr progeny born per year",480,{"$nulls":9},{"$f":"L7+1","v":3},{"v":0.730396884544797,"d":"0.730"},{"v":0.6456742246778457,"d":"0.646"},{"$f":"O7+1","v":3},{"v":451.63199999999995,"d":"452"},{"v":5.213790608643043,"d":"5.21"},{"v":2.4071319264357702E-4,"d":"0.0"},{"v":2.9121056334750327E-4,"d":"0.0"},{"v":4,"d":"4.0"},{"v":70,"d":"70.0"}]
["mortality rate ",{"v":0.03,"d":"3%"},{"$nulls":9},4,{"v":0.8313718647968797,"d":"0.831"},{"v":0.6657470376312724,"d":"0.666"},4,{"v":438.0830399999999,"d":"438"},{"v":4.468963378836894,"d":"4.47"},{"v":4.785096541121802E-8,"d":"0.0"},{"v":6.6500867008834052E-9,"d":"0.0"},{"v":1,"d":"1.0"},{"v":60,"d":"60.0"}]
["Earliest possible age of first drop males",1,{"$nulls":9},5,{"v":0.8770393416912106,"d":"0.877"},{"v":0.6835707278398025,"d":"0.684"},5,{"v":424.94054879999993,"d":"425"},{"v":3.724136149030745,"d":"3.72"},{"v":1.4625142222612906E-12,"d":"0.0"},{"v":0,"d":"0.0"},{"v":1,"d":"1.0"},{"v":40,"d":"40.0"}]
["Earliest possible age of first drop females ",1,{"$nulls":9},6,{"v":0.9031869986098401,"d":"0.903"},{"v":0.6995192295083766,"d":"0.700"},6,{"v":412.19233233599994,"d":"412"},{"v":2.979308919224596,"d":"2.98"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":30,"d":"30.0"}]
["Max age class (years)",10,{"$nulls":9},7,{"v":0.9201470659088492,"d":"0.920"},{"v":0.7138846633072738,"d":"0.714"},7,{"v":399.8265623659199,"d":"400"},{"v":2.234481689418447,"d":"2.23"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"}]
[{"$nulls":11},8,{"v":0.9320440617702691,"d":"0.932"},{"v":0.726899333500907,"d":"0.727"},8,{"v":387.8317654949423,"d":"388"},{"v":1.489654459612298,"d":"1.49"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"}]
["Optimized Generation Interval       0/1","YES",{"$nulls":9},9,{"v":0.9408527463608398,"d":"0.941"},{"v":0.7387507796497678,"d":"0.739"},9,{"v":376.19681253009406,"d":"376"},{"v":0.744827229806149,"d":"0.74"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"}]
["gestation length (years)",0.42,{"$nulls":9},10,{"v":0.9476383317551597,"d":"0.948"},{"v":0.7495923757133157,"d":"0.750"},10,{"v":364.91090815419125,"d":"365"},{"v":0,"d":"0.00"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"},{"v":0,"d":"0.0"}]
["parentage",2,{"$nulls":7},"Standard Deviation of Breeding Objective",null,null,{"v":0.544129535630871,"d":"$0.54"},{"$nulls":4},20,60,{"$f":"SUM(T6:T15)","v":{"v":10,"d":"10.0"}},{"$f":"SUM(U6:U15)","v":{"v":300,"d":"300.0"}}]
["percent index emphasis males",{"v":1,"d":"100%"},{"$nulls":7},"RESULTS",null,"Previous Run","Latest Run","Difference",null,null,"Average age of parents",{"v":1.0086744960058756,"d":"1.01"},{"v":1.0097929579855027,"d":"1.01"},{"$f":"MMULT(TRANSPOSE(O6:O15),T6:T15)/T16","v":{"v":2.9,"d":"2.90"}},{"$f":"MMULT(TRANSPOSE(O6:O15),U6:U15)/U16","v":{"v":3.433333333333333,"d":"3.43"}}]
["percent index emphasis females",{"v":1,"d":"100%"},{"$nulls":8},"$Response/Year",{"v":0.8776123834611675,"d":"0.88"},{"v":0.7448716357800856,"d":"0.74"},{"v":-0.15125213611682747,"d":"-15.1%"}]
["INDEX USED",null,"index contains            "," ",{"$nulls":6},"Index Accurcay",{"v":0.7560498928223632,"d":"0.76"},{"v":0.7284564518577907,"d":"0.73"},{"v":-0.03649685189632807,"d":"-3.6%"},{"$f":"M16^2","v":{"v":0.2960769515458673,"d":"0.296"}}]
["I1",2,"traits ",{"$nulls":7},"gen_interval males",{"v":1.0089845566826987,"d":"1.01"},{"v":1.0086744960058756,"d":"1.01"},{"v":3.0729972502508833E-4,"d":"0.0%"},{"$f":"L19^2*O19","v":0.1692409727532423}]
[null,"Trait","Trait","Trait","Age at",null,"Trait",{"$nulls":3},"gen_interval females",{"v":1.0103053723579822,"d":"1.01"},{"v":1.0097929579855027,"d":"1.01"},{"v":5.0718761524901025E-4,"d":"0.1%"}]
["TRAIT RECORDING","Abbreviation","Measurement","Measurement","Measurement","Economic","Measured","Genomic ",{"$nulls":3},"                     Response/Year",null,null,"            Response/year",null,"       EBV accuracies ",null,"  EBV accuracies young males"]
[null,null,"Males","Females","in time units","Value"," in RefPop 0/1","reliability",{"$nulls":3},"                     in trait units",null,null,"                 in $ Value",null,"averaged of selected parents",null,"  age class 2 selected at 18 mo"]
["Genotyping","DNA",1,1,{"$nulls":5},"Trait","units",{"$f":"L17","v":"Previous Run"},{"$f":"M17","v":"Latest Run"},"%change",{"$f":"L24","v":"Previous Run"},{"$f":"M24","v":"Latest Run"},{"$f":"L24","v":"Previous Run"},{"$f":"M24","v":"Latest Run"},{"$f":"L24","v":"Previous Run"},{"$f":"M24","v":"Latest Run"}]
["Trait 1","t1",1,1,0.2,{"v":1,"d":"1.00"},1,{"v":0.64,"d":"0.6400"},null,"t1",null,{"v":0.832871008191258,"d":"0.83"},{"v":0.8277331153145208,"d":"0.83"},{"v":-0.006168893893779792,"d":"-1%"},{"v":0.83,"d":"$0.83"},{"v":0.8277331153145208,"d":"$0.83"},{"v":0.8447073523111022,"d":"0.84"},{"v":0.8453958585640232,"d":"0.85"},{"v":0.8444072720904994,"d":"0.84"},{"v":0.8455069939149901,"d":"0.85"},{"$f":"T25/S25","v":1.0013023594903063}]
["Trait 2","t2",1,1,0.2,{"v":1,"d":"1.00"},0,{"v":0.64,"d":"0.6400"},null,"t2",null,{"v":0.044741375269909525,"d":"0.04"},{"v":-0.0828614795344351,"d":"-0.08"},{"v":-2.8520101144535666,"d":"-285%"},{"v":0.04,"d":"$0.04"},{"v":-0.0828614795344351,"d":"$(0.08)"},{"v":0.4245546844953586,"d":"0.42"},{"v":0.47331356532440144,"d":"0.47"},{"v":0.42366576280004076,"d":"0.42"},{"v":0.4727579693207266,"d":"0.47"}]
[{"$nulls":9},"I1","$",{"v":0.8776123834611675,"d":"0.88"},{"v":0.7448716357800856,"d":"0.74"},{"v":-0.15125213611682747,"d":"-15%"},{"v":0.8776123834611675,"d":"$0.88"},{"v":0.7448716357800856,"d":"$0.74"},{"v":0.7560498928223632,"d":"0.76"},{"v":0.7284564518577907,"d":"0.73"},{"v":0.7554086687814209,"d":"0.76"},{"v":0.7281791497725917,"d":"0.73"}]
{"$rows_empty":32}
[{"$nulls":9},{"$f":"(T25-S25)/S25","v":{"v":1.3023594903062762E-3,"d":"0%"}},{"$f":"N19","v":{"v":-0.03649685189632807,"d":"-3.6%"}},{"$f":"N18","v":{"v":-0.15125213611682747,"d":"-15.1%"}}]

{"sheet":"Genetic Parameters","index":2,"n_rows":67,"n_cols":68,"rows_kept":67}
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[null,"ABBREV","UNITS",null,null,"H2",{"$f":"B3","v":"t1"},{"$f":"B4","v":"t2"},{"$nulls":59},"Economic value"]
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["Trait 2","t2",{"$nulls":3},{"v":0.1,"d":"0.100"},-0.3,0.1,{"$nulls":59},0]
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[{"$nulls":6},"Phenotypic variance-correlation matrix (first bunch is zero, these are objective traits"]
[{"$nulls":6},"conf","dress"]
[{"$f":"A3","v":"Trait 1"},{"$f":"B3","v":"t1"},{"$nulls":4},1,-0.5]
["Trait 2",{"$f":"B4","v":"t2"},{"$nulls":4},-0.5,1]

{"sheet":"Selection Index Sheet","index":3,"n_rows":152,"n_cols":43,"rows_kept":152,"merged":[[2,3,2,7],[3,3,4,3],[3,4,4,4],[3,5,4,5],[3,6,4,6],[3,7,4,7]]}
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[2,"Nr of traits  ",null,"Parameters",{"$nulls":16},"sex",1]
["  ",null,null,"Phenotypic Stand. Dev.","Heritability","Repeatability","c2 among full sibs","Economic Value","              Genetic  Stand. Deviation",null,"Trait","Age first","Genomic",null,"Number of records",{"$nulls":5},"Male","Female","Male","Female"]
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[2,"t2",null,{"v":1,"d":"1.00"},{"v":0.1,"d":"0.10"},{"v":0.30000000000000004,"d":"0.30"},{"v":0,"d":"0.00"},{"v":1,"d":"1.00"},{"v":0.31622776601683794,"d":"0.32"},{"v":0.31622776601683794,"d":"0.32"},2,0.2,{"v":0,"d":"0.00"}]
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{"sheet":"Economic values - Indexes","index":4,"n_rows":41,"n_cols":4,"rows_kept":41}
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["trait abbrev need to correspond with       Genetic Parameters","Merino Index Economic Values"]
["INDEX","I1","I2","I3"]
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["t2",{"v":1,"d":"1.00"},{"v":1,"d":"1.00"},{"v":1,"d":"1.00"}]
{"$rows_empty":28}
[null,{"$f":"TRANSPOSE(B3:I3)","v":"I1"}]
[null,"I2"]
[null,"I3"]
[null,0]
[null,0]
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[null,0]
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{"sheet":"Age optimization","index":5,"n_rows":130,"n_cols":26,"rows_kept":130,"hidden":true}
[{"$nulls":9},"     Threshold"]
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[]
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[]
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[]
[]
[]
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[]
[]
[null,"Responses",null,"numbers per trait are genetic chnages per unit of SD, in the mean they are weighted 9and multiplied) by selection intensity"]
[{"$nulls":21},"Average","Average","Average"]
["age",1,2,3,4,5,6,7,8,{"$nulls":11},10,"males","females","overall",null," "]
["sex",1,1,1,1,1,1,1,1,{"$nulls":11},2,"GenInterv","GenInterv","GenInterv"]
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[]
["t1",{"$nulls":20},0.9377667910686597,0.7329855627845928,0.8277331153145208]
["t2",{"$nulls":20},-0.0936028437201547,-0.07365035590967516,-0.0828614795344351]
["pwt",{"$nulls":20},2.471533319800867,0.5918564368541012,0.3802875735003899]
["pemd",{"$nulls":20},0.16620342942692545,0.03564606783242674,0.025057489128921924]
["pfat",{"$nulls":20},-0.022951852446444588,-0.003456401533011823,-3.2783065897548517E-3]
["pfec",{"$nulls":20},0.14890852843914587,0.03837398987477819,0.02324915211782051]
["ywt",{"$nulls":20},3.894265006855548,0.9678358186090082,0.6035786079826644]
["yemd",{"$nulls":20},0.22996934556927612,0.052362378401760834,0.035048509905695406]
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["yfec",{"$nulls":20},0.24368420654957443,0.06481507305925992,0.03829693633145995]
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["conf",{"$nulls":20},0,0,0]
["dress",{"$nulls":20},0.48951246727222114,0.11746483883966206,0.07534983963749328]
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["long",{"$nulls":20},0,0,0]
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{"$rows_empty":8}
[{"$nulls":22},23,24,25,26]
{"$rows_empty":14}
[null,"Accuracies"]
[]
[{"$f":"A36","v":"age"},1,2,3,4,5,6,7,8,9,10,1,2,3,4,5,6,7,8,9,10,"mean","mean","mean"]
[{"$f":"A37","v":"sex"},1,1,1,1,1,1,1,1,1,1,2,2,2,2,2,2,2,2,2,2,"males","females","all"]
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[]
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