import pandas as pd
import numpy as np

raw_data = {'first_name': ['Jason', 'Molly', 'Tina', 'Jake', 'Amy'], 
        'last_name': ['Miller', 'Jacobson', 'Ali', 'Milner', 'Cooze'], 
        'age': [42, 52, 36, 24, 73], 
        'preTestScore': [-999, -999, -999, 2, 1],
        'postTestScore': [2, 2, -999, 2, -999]}
df = pd.DataFrame(raw_data, columns = ['first_name', 'last_name', 'age', 'preTestScore', 'postTestScore'])
df

df.replace(-999, np.nan)